Failure of montelukast to reduce sputum eosinophilia in high-dose corticosteroid-dependent asthma

Failure of montelukast to reduce sputum eosinophilia in high-dose corticosteroid-dependent asthma.

Sputum eosinophilia is a sensitive predictor of benefit from corticosteroid treatment. Montelukast is a cysteinyl leukotriene antagonist, which also reduces sputum and blood eosinophils. The present study examined the possibility that montelukast has an added eosinophil-lowering effect in subjects with asthma who are corticosteroid responsive but relatively corticosteroid resistant. A total of ...

Failure of sputum eosinophilia after eotaxin inhalation in asthma.

BACKGROUND Eotaxin is a chemokine specific for eosinophils and may play an important role in eosinophil recruitment in asthma. The effects of eotaxin inhalation on sputum and blood eosinophils, exhaled nitric oxide (NO), and bronchial responsiveness were determined. METHODS Eotaxin was administered by nebulisation to asthma patients in three studies: (1) an open dose finding study with eotaxi...

Is sputum eosinophilia a good or poor predictor of benefit from inhaled corticosteroid therapy in asthma?

Exacerbations of asthma without sputum eosinophilia.

BACKGROUND Sputum analysis provides a non-invasive method of examining the airway secretions of subjects with asthma in order to better understand the inflammatory process. Increased proportions of eosinophils are generally seen in the sputum of subjects with asthma, especially when there is an exacerbation. An unexpected observation in the sputum of subjects with mild exacerbations of asthma i...

Chronic sinusitis in severe asthma is related to sputum eosinophilia.

BACKGROUND Chronic rhinosinusitis and asthma are conditions that frequently coexist, particularly in severe asthma. The precise mechanism of the relationship between upper and lower airway inflammation is still a matter of debate. We hypothesized that the extent of inflammation in the nasal mucosa is related to lung function and inflammation in the bronchial mucosa in patients with severe asthm...